gpr171 inhibitor Search Results


gpr171 inhibitor  (Tocris)
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Tocris gpr171 inhibitor
(A and B) Radar plots showing age-corrected associations (Imm FDRT1D:FDRcontrol) of all module eigengenes (shown around plot circumference) with time to T1D onset in IAAs-first (A) and GADA-first (B) cases. Disease specificity indicated by a T1D:control significance ratio > 1 (−log10FDR) = red line. (C and D) Line plots showing individual and summary (inset) effects of natural cubic spline–fitted lmm (±95% CI) fitted to IAAsig (C) or GADAsig (D) eigenvalues in cases (left) and matched controls (right). (E and F) Radar plot (E) and barplot (F) showing IAAs module enrichment for cell type–specific transcripts compared to ARCHS4 (E) and DICE (F) relational databanks. (G) Volcano plot (left) and line plots (right) showing all (left) and selected (right) correlations (Pearson) of IAAsig eigengenes against deconvoluted cell proportions. Significance threshold (FDR < 5%) = red dashed line. (H to J) Radar plot (H) and barplot (I) showing IAAs module enrichment for cell type–specific transcripts compared to ARCHS4 (H) and DICE (I) relational databanks. (J) Volcano plot (left) and line plots (right) showing all (left) and selected (right) correlations (Pearson) of GADAsig eigengenes against deconvoluted cell proportions. Significance threshold (FDR < 5%) = red dashed line. For barplots (F and I), TPM, transcripts per million reads; expression (means ± SEM) of IAAsig (F) and GADAsig (I) per cell type is shown. (K) Radar plot showing enrichment (−log10FDR) of IAAsig genes against 352 druggable targets linked to 20,883 genes from the IDG repository. Drug targets showing any overlap with IAAsig genes are included around the radar plot circumference. (L) Barplot (means ± SEM, n = 3 to 12 per group) showing IAAsig eigengene expression and (M) representative histograms showing <t>GPR171</t> surface protein expression in circulating immune cell subsets (GSE22886). (N) Representative contour plot (top) and scatterplot (bottom) showing GPR171 surface protein expression (y axis, log10 MFI) and Granzyme B (GZMB) protein expression (x axis) after coculture of purified primary human NK cells with K562 target cells along with vehicle (left) or a titrated dose range of specific GPR171 inhibitor (Inh; right). *P < 0.05, MFI, median fluorescence index; Treg, regulatory T cell.
Gpr171 Inhibitor, supplied by Tocris, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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(A and B) Radar plots showing age-corrected associations (Imm FDRT1D:FDRcontrol) of all module eigengenes (shown around plot circumference) with time to T1D onset in IAAs-first (A) and GADA-first (B) cases. Disease specificity indicated by a T1D:control significance ratio > 1 (−log10FDR) = red line. (C and D) Line plots showing individual and summary (inset) effects of natural cubic spline–fitted lmm (±95% CI) fitted to IAAsig (C) or GADAsig (D) eigenvalues in cases (left) and matched controls (right). (E and F) Radar plot (E) and barplot (F) showing IAAs module enrichment for cell type–specific transcripts compared to ARCHS4 (E) and DICE (F) relational databanks. (G) Volcano plot (left) and line plots (right) showing all (left) and selected (right) correlations (Pearson) of IAAsig eigengenes against deconvoluted cell proportions. Significance threshold (FDR < 5%) = red dashed line. (H to J) Radar plot (H) and barplot (I) showing IAAs module enrichment for cell type–specific transcripts compared to ARCHS4 (H) and DICE (I) relational databanks. (J) Volcano plot (left) and line plots (right) showing all (left) and selected (right) correlations (Pearson) of GADAsig eigengenes against deconvoluted cell proportions. Significance threshold (FDR < 5%) = red dashed line. For barplots (F and I), TPM, transcripts per million reads; expression (means ± SEM) of IAAsig (F) and GADAsig (I) per cell type is shown. (K) Radar plot showing enrichment (−log10FDR) of IAAsig genes against 352 druggable targets linked to 20,883 genes from the IDG repository. Drug targets showing any overlap with IAAsig genes are included around the radar plot circumference. (L) Barplot (means ± SEM, n = 3 to 12 per group) showing IAAsig eigengene expression and (M) representative histograms showing GPR171 surface protein expression in circulating immune cell subsets (GSE22886). (N) Representative contour plot (top) and scatterplot (bottom) showing GPR171 surface protein expression (y axis, log10 MFI) and Granzyme B (GZMB) protein expression (x axis) after coculture of purified primary human NK cells with K562 target cells along with vehicle (left) or a titrated dose range of specific GPR171 inhibitor (Inh; right). *P < 0.05, MFI, median fluorescence index; Treg, regulatory T cell.

Journal: Science translational medicine

Article Title: Transcriptional networks in at-risk individuals identify signatures of type 1 diabetes progression

doi: 10.1126/scitranslmed.abd5666

Figure Lengend Snippet: (A and B) Radar plots showing age-corrected associations (Imm FDRT1D:FDRcontrol) of all module eigengenes (shown around plot circumference) with time to T1D onset in IAAs-first (A) and GADA-first (B) cases. Disease specificity indicated by a T1D:control significance ratio > 1 (−log10FDR) = red line. (C and D) Line plots showing individual and summary (inset) effects of natural cubic spline–fitted lmm (±95% CI) fitted to IAAsig (C) or GADAsig (D) eigenvalues in cases (left) and matched controls (right). (E and F) Radar plot (E) and barplot (F) showing IAAs module enrichment for cell type–specific transcripts compared to ARCHS4 (E) and DICE (F) relational databanks. (G) Volcano plot (left) and line plots (right) showing all (left) and selected (right) correlations (Pearson) of IAAsig eigengenes against deconvoluted cell proportions. Significance threshold (FDR < 5%) = red dashed line. (H to J) Radar plot (H) and barplot (I) showing IAAs module enrichment for cell type–specific transcripts compared to ARCHS4 (H) and DICE (I) relational databanks. (J) Volcano plot (left) and line plots (right) showing all (left) and selected (right) correlations (Pearson) of GADAsig eigengenes against deconvoluted cell proportions. Significance threshold (FDR < 5%) = red dashed line. For barplots (F and I), TPM, transcripts per million reads; expression (means ± SEM) of IAAsig (F) and GADAsig (I) per cell type is shown. (K) Radar plot showing enrichment (−log10FDR) of IAAsig genes against 352 druggable targets linked to 20,883 genes from the IDG repository. Drug targets showing any overlap with IAAsig genes are included around the radar plot circumference. (L) Barplot (means ± SEM, n = 3 to 12 per group) showing IAAsig eigengene expression and (M) representative histograms showing GPR171 surface protein expression in circulating immune cell subsets (GSE22886). (N) Representative contour plot (top) and scatterplot (bottom) showing GPR171 surface protein expression (y axis, log10 MFI) and Granzyme B (GZMB) protein expression (x axis) after coculture of purified primary human NK cells with K562 target cells along with vehicle (left) or a titrated dose range of specific GPR171 inhibitor (Inh; right). *P < 0.05, MFI, median fluorescence index; Treg, regulatory T cell.

Article Snippet: Purified NK cells were cultured for 48 hours in complete RPMI 1640 in the presence of target K562 cells and either a GPR171 inhibitor (MS21570, Tocris Bio-Techne) or vehicle (phosphate-buffered saline) and stained with an excess of antibodies against GPR171 (polyclonal rabbit anti-human GPR171, Abcam), CD71 (clone CY1G4, BioLegend), and Granzyme B (clone GB11, BioLegend).

Techniques: Expressing, Purification, Fluorescence